Our Research Focus

Synthetic chemistry has the power to enable far-reaching investigations into human biology. Research in the Spiegel lab focuses on organic synthesis, with a specific emphasis on developing new methods and molecules that will facilitate our understanding and treatment of human disease. Ongoing projects range from synthetic reaction development and natural product synthesis to the construction of functional molecules capable of accomplishing specific biological tasks.


February 29, 2024

Congrats to Dr Rebecca Howell for successfully defending her thesis entitled ‘Bifunctional Molecules that induce both degradation and transcytosis of extracellular...

April 6, 2023

Rinco Wang joins the lab as a PhD graduate student. Welcome!

April 3, 2023

Muthukumaran Venkatachalapathy joins as an Associate Research Scientist. Welcome!

December 1, 2022

Shikha Kumari joins the lab as an Associate Research Scientist. Welcome!

November 22, 2022

Eddie deRamon has successfully defended his thesis entitled “Therapeutic depletion of pathogenic autoantibodies using...

November 21, 2022

Congratulations Eddie, Venkata, Matt, Yannan, Tim and David on their recent publication of Pentosinane, a post...

November 21, 2022

Jovan Lopez joins the lab as an MD/PhD graduate student. Welcome!

September 1, 2022

Chhanda Danta joins the lab as a postdoctoral researcher. Welcome!

February 28, 2022

Robert Hale has successfully defended his thesis entitled “Two Projects Informed by Work on Glucosepane”- Congrats Dr....

December 1, 2021

Mihir Khambete joins the lab as a postdoctoral fellow. Welcome!

August 19, 2021

Congrats to Dave, Clarice, Jason, Rebecca, Jake, Emily, Egor, Venkata, Angela, David and Vish on their latest paper on...

February 28, 2021

David was awarded the 2021 Falk Catalyst Award for high-risk high-reward biomedical research. This will fund research for the...

September 28, 2020

Dave Caianiello has successfully defended his thesis entitled “Bifunctional molecules that mediate the degradation of...

September 25, 2020

Congrats to Matt on his latest paper on the Generation and Characterization of Anti-Glucosepane Antibodies...

June 17, 2020

Congrats to Robert on passing his anti-thesis exam!

June 6, 2020

Jesse Collinksi has successfully defended his thesis entitled “Improving cell-targeted therapeutics”- Congrats Dr. Collinski!

June 1, 2020

Congratulations Jason on passing his qualifying exam!

May 18, 2020

Congratulations to Rebecca on passing her qualifying exam!

April 22, 2020

Congratulations to Eddie on passing his qualifying exam!

January 15, 2020

Congratulations to Theo on graduating with his Masters Degree in Chemistry and accepting an Associate Scientist position at Sanofi!

November 12, 2019

Congrats to Venkata on his latest paper published in Angewandte Chemie!

June 18, 2019

Jason has joined the lab as a graduate student. Welcome!

May 8, 2019

Eddie and Rebecca have joined the lab as graduate students. Welcome!

July 10, 2018

Theo has joined the lab as a graduate student. Welcome! 

June 22, 2018

Congratulations to Matt Streeter for winning a Poster Prize at the Bioorganic Gordon Research Conference 2018!

May 23, 2018

Jake and Emily have joined the lab as graduate student researchers. Welcome! 

April 3, 2018

Angela was awarded a Yale College First-Year Summer Research Fellowship in the Sciences and Engineering. Congrats Angela! 

February 12, 2018

Angela and Seungjung have joined the lab as undergraduate researchers. Welcome! 

February 12, 2018

David McDonald has joined the lab from the University of Sydney as a postdoc. Welcome! 

September 11, 2017

Congratulations to Egor and Vish on their recent paper in ACIE

July 20, 2017

Dr. Sumantha Bhatt has joined the lab as Director of Research Communications. Welcome! 

March 9, 2017

Congrats to Julian, Tina, and Thi for their latest paper in ACS Combi Sci!

January 23, 2017

For receiving the Visionary Award from the American Diabetes Association,...

November 1, 2016

Congrats to Matt on passing his anti-thesis exam, fantastic work!

August 1, 2016

Congrats to Matt Streeter for winning the Poster Prize at the Tri-institutional Chemical Biology Symposium at Memorial Sloan Kettering Cancer Center!

May 1, 2016

Congratulations to Jesse Collins on passing his qualifying exam!

May 1, 2016

Congratulations to Mengwen Zhang on passing her qualifying exam!

March 1, 2016

Julian has successfully defended his thesis entitled “Encoded Silicon Chips and Novel Oligomers for Solid Phase Synthesis and Screening” - Congrats, Dr. Vastl!

February 1, 2016

See Anthony and Vish’s paper on Re-engineering the Immune Response - fantastic work!

Chemical Science
February 1, 2016

Congrats to Julian on his latest paper on Peptidines published in Chemical...

November 1, 2015

Congratulations to Nichole Johnston on passing her qualifying exam!

November 1, 2015

Congratulations to Nancy on her latest work on nanobodies, just published in Chembiochem!

October 1, 2015

Cristian and Tina’s paper on the synthesis of glucosepane is now published in Science! Read about it here...

September 1, 2015

Click here to see David on ‘SciTech Now’, discussing our fascinating work on...

August 1, 2015

We are excited to announce that Allied-Bristol Life Sciences (ABLS) has licensed our immuno-oncology platform and lead molecules known as Antibody-Recruiting Molecules (...

2016 Arthur C. Cope Scholar Awards
August 1, 2015

Congratulations to David - a recipient of the...

July 1, 2015

See Tina and Matt’s paper “Generation and Characterization of Antibodies Against Arginine-derived Advanced Glycation End Products” in...

June 1, 2015

Samir and Phil’s paper, “Chemical Probes Reveal an Extraseptal Mode of Cross-Linking in Staphylococcus aureus” is now published in JACS. Check it out...

May 1, 2015

Group alum, Eugene Douglass, has received the renowned NAGS Dissertation Award! His dissertation on “Understanding Drugs That Bind Multiple Targets” was recognized by the...

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May 1, 2015

Matt Streeter passes his 2nd Year Qualifying Exam…way to go, Matt!

May 1, 2015

Kelly Fitzgerald has successfully defending her dissertation entitled “Small Molecule Immunomodulators as Cancer Therapeutics”. Congrats, Dr. Fitzgerald!

April 1, 2015

Congrats to Jaylissa and Sarah on getting their NSF grant applications funded - marvelous work!

February 1, 2015

Congratulations to Tina for successfully defending her thesis entitled “Chemical Perspectives on Protein Glycation” - excellent work, Dr. Wang!

February 1, 2015

See highlights of the lab’s recent article, reporting the first synthetic molecules that possess both the targeting and effector functions of antibodies, in the following...

January 1, 2015

The Spiegel Lab is excited to announce its newest graduate students: Sarah Malkowski, Joseph Piechocki, Jaylissa Torres, and Mengwen (Clarice) Zheng. Welcome!

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December 1, 2014

Congratulations to Patrick and Kelly on their paper entitled “Chemically Synthesized Molecules with the Targeting and Effector Functions of Antibodies”, now published...

May 1, 2014

Congratulations to David on his promotion to full Professor at Yale!

April 1, 2014

Check out Chris and Nancy’s paper “Illuminating HIV-1 gp120­Ligand Recognition through Computationally-Driven Optimization of Antibody-Recruiting Molecules” in...

November 1, 2013

Congratulations to Phil on his work on developing a liver-targeting mitochondrial uncoupler that can serve as a potential therapeutic agent for hypertriglyceridemia, non-...

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September 1, 2013

Thihan & Patrick’s chapter on Synthetic Immunology is published in the book “Biotherapeutics: Recent Developments using Chemical and Molecular Biology...

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September 1, 2013

Chuck’s paper identifying immune effector functions of natural human antibodies against various synthetic antibody recruiting molecules is now published in...

August 1, 2013

Check out Tina’s recent JACS paper highlighting the development of a “turn-on” fluorescent sensor...

June 1, 2013

Congratulations to Phil on his publication in Tetrahedron, which highlights the...

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April 1, 2013

Eugene’s paper is accepted to JACS!
This publication provides a comprehensive mathematical framework for understanding ternary complex...

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April 1, 2013

Congratulations to Samir and Phil on their recent review article in Trends in Biotechnology. The article highlights strategies to functionalize bacterial...

December 1, 2012

David is awarded $3.6 million as a Department of Defense Era of Hope Scholar Award recipient. This will fund research for the development of a...

November 1, 2012

Congratulations to Phil Kim on the acceptance of his manuscript disclosing the unique reactivity of N-phenacyl-derived thiazolium salts toward alpha-dicarbonyl compounds....

September 1, 2012

Andrew Zhang becomes the inaugural Spiegel Group member to defend his thesis. Congratulations Dr. Zhang!

August 1, 2012

See David’s live UStream press conference on ARMs research during the Philadelphia National...

July 1, 2012

A big welcome to Mia Huang, the group’s newest Postdoctoral Associate, who comes to us from Kent Kirshenbaum ‘s lab at NYU!

July 1, 2012

The group’s review on antibody-recruiting molecules is published in...

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June 1, 2012

David is the host of a Synthetic Immunology Ask the Expert forum on the ACS Chemical Biology community website. Post a question, thought, or comment here:...

April 1, 2012

The group reports their research into post-translational arginine modifications in JACS.

November 1, 2011

Congratulations to Chad Miller and Kelly Fitzgerald on passing their Pharmacology qualifying exams!

November 1, 2011

We proudly announce that David has been awarded a Novartis Early Career Award in Organic Chemistry for outstanding research within 10 years of starting his independent...

October 1, 2011

We are pleased to welcome Postdoctoral Associate Cristian Draghici, who comes to us from the lab of Jon Njardarson at Arizona.

June 1, 2011

Congratulations to Chuck Jakobsche who was recently awarded a prestigious NIH Ruth Kirschstein postdoctoral fellowship through the National Cancer Institute.

May 1, 2011

The Spiegel Group welcomes newest members Samir Gautam, Chad Miller and Julian Vastl.

March 1, 2011

Watch David’s Advanced Glycation End-products presentation at the SENS-5 Conference in Cambridge, England....

February 1, 2011

Congratulations to David for being named one of this year’s recipients of the Alfred P. Sloan Foundation Research Fellowship!

February 1, 2011

A highlight of the lab’s work on antibody-recruiting molecules is published in the...

January 1, 2011

The Spiegel Group is pleased to welcome newest group members, graduate students Nancy Tao and Kelly Fitzgerald, and laboratory associate, Dr. Takuji Shoda.

November 1, 2010

Congratulations to David for being selected as one of the winners of this year’s Nature Chemical Biology Grand Challenges Essay Contest.  His essay,...

November 1, 2010

Our article in ACS Chemical Biology about re-engineering the Staphylococcus aureus cell wall with non...

October 1, 2010

Our strategy for biosynthetically incorporating small molecules into the Staphylococcus aureus cell wall is published in...

September 1, 2010

Our recent article about the discovery of a novel arene binding site on
prostate specific membrane antigen by ARM-Ps has been highlighted in...

August 1, 2010

The group reports investigations into antibody-recruiting small molecules targeting prostate cancer (ARM-Ps) in ...

June 1, 2010

Congratulations to group members Phil Kim and Eugene Douglass for passing their oral exams!

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April 1, 2010

The lab’s work on antibody-recruiting molecules targeting prostate
cancer has been highlighted in...

March 1, 2010

We are pleased to announce recent press coverage of antibody-recruiting small molecules targeting HIV and prostate cancer. This work has been highlighted in numerous...

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March 1, 2010

The Spiegel Group is pleased to welcome their newest member, graduate student Tina Wang.

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March 1, 2010

Congratulations to Jason Gandelman, a senior at Staples High School, for being named one the 40 finalists in the Intel Science Talent Search!  Jason has been working on a...

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February 1, 2010

The lab’s recent article involving antibody-recruiting small molecules targeting prostate cancer is reviewed as a “must read” paper on the Faculty of 1000, and is...

January 1, 2010

Recent Spiegel group publications on Antibody-Recruiting have been spotlighted in ACS Chemical Biology.  Congratulations to Andrew, Chris, and Ryan!...

November 1, 2009

The group reports a novel strategy for recruiting endogenous antibodies to prostate cancer cells. Congratulations to Ryan and Andrew!...

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October 1, 2009

The group reports a novel small-molecule-based strategy for enhancing immune recognition of HIV. Congratulations to Chris Parker!...

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September 1, 2009

Welcome to new postdoctoral researcher Chuck Jakobsche, coming from Scott Miller’s group at Yale, and visiting researcher Alex Chamessian from Stony Brook University...

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January 1, 2009

The Spiegel Group welcomes new graduate student group members Eugene Douglass, Taehan (Phil) Kim and...

October 1, 2008

The Spiegel Group welcomes postdoctoral researcher Rendy Kartika, coming from Richard E. Taylor’s group at University of Notre Dame.

September 1, 2008

Congratulations David on being named one of this year’s recipients of the Ellison Medical Foundation New...

July 1, 2008

Welcome to postdoctoral researcher Mariya Kolesnikova, who comes to us from Seiichi Matsuda’s group at Rice University.

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March 1, 2008

Welcome to new group members Chris Parker, Alison Wendlandt, Andrew Zhang, James Nelson, and Patrick McEnaney...

January 1, 2008

Read an article about research in the Spiegel Lab in the Yale Daily News.

September 1, 2007

David Spiegel was recently named one of the first recipients of the NIH Director’s New...